PSME2

Clone Type

Polyclonal

Host

Rabbit

Source

Human

Swiss Prot

Q9UL46

Isotype

IgG

Grade

Affinity Purified

Applications

E WB

Crossreactivity

Shipping Temp

Blue Ice

Storage Temp

-20°C

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

Applications

Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution

Optimal dilutions to be determined by the researcher.

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunogen

Recombinant corresponding to proteasome activator complex subunit 2.

Form

Supplied as a liquid in PBS.

Purity

Purified by Protein G affinity chromatography.

Specificity

Recognizes human PSME2.

References

1. "Organization of the genes encoding the human proteasome activators PA28alpha and beta." McCusker D., Wilson M., Trowsdale J. Immunogenetics 49:438-445 (1999). 2. "Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome." Ahn J.Y., Tanahashi N., Akiyama K., Hisamatsu H., Noda C., Tanaka K., Chung C.H., Shibmara N., Willy P.J., Mott J.D., Slaughter C.A., DeMartino G.N. FEBS Lett. 366:37-42 (1995). 3. "The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J. Nature 421:601-607 (2003). 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team

USBio References

No references available

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029280 Rabbit Anti-PSME2 (Proteasome Activator Complex Subunit 2, Proteasome Activator 28 Subunit beta, PA28beta, PA28b, Activator Of Multicatalytic Protease Subunit 2, 11S Regulator Complex Subunit beta, REG-beta)

Clone Type

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Swiss Prot

Isotype

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Crossreactivity

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References

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