CD279

Clone Type

Monoclonal

Host

Mouse

Source

Human

Swiss Prot

Q15116

Conjugate

FITC

Isotype

IgG1,k

Clone Number

EH12.2H7

Grade

Purified

Applications

Crossreactivity

Hu Mk

Gene ID

5133

Shipping Temp

Blue Ice

Storage Temp

-20°C

CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its ligands CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.

Applications

Suitable for use in Flow Cytometry. Other applications not tested.

Recommended Dilution

Flow Cytometry: 4ul labels 10e6 cells in 100ul Optimal dilutions to be determined by the researcher.

Storage and Stability

Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunogen

Recombinant human CD279

Form

Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide. Labeled with Fluorescein isothiocyanate (FITC).

Purity

Purified

Specificity

Recognizes human CD279. Species Crossreactivity: primate

References

1. Xu Y, Weatherall C, Bailey M, Alcantara S, De Rose R, Estaquier J, Wilson K, Suzuki K, Corbeil J, Cooper DA, Kent SJ, Kelleher AD, Zaunders J: Simian immunodeficiency virus infects follicular helper CD4 T cells in lymphoid tissues during pathogenic infection of pigtail macaques. J Virol. 2013 Apr;87(7):3760-73.|2. Gros A, Robbins PF, Yao X, Li YF, Turcotte S, Tran E, Wunderlich JR, Mixon A, Farid S, Dudley ME, Hanada K, Almeida JR, Darko S, Douek DC, Yang JC, Rosenberg SA: PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors. J Clin Invest. 2014 May;124(5):2246-59.|3. Černý V, Hrdý J, Novotná O, Petrásková P, Boráková K, Kolářová L, Prokešová L: Distinct characteristics of Tregs of newborns of healthy and allergic mothers. PLoS One. 2018 Nov 26;13(11):e0207998.|4. Li H, Pauza CD: CD25(+) Bcl6(low) T follicular helper cells provide help to maturing B cells in germinal centers of human tonsil. Eur J Immunol. 2015 Jan;45(1):298-308.

USBio References

No references available

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046241-FITC Mouse Anti-CD279 (PD-1, Programmed Cell Death 1) (FITC)

Clone Type

Host

Source

Swiss Prot

Conjugate

Isotype

Clone Number

Grade

Applications

Crossreactivity

Gene ID

Shipping Temp

Storage Temp

References

USBio References

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