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350500 Rabbit Anti-ROBO1, CT (Roundabout homolog 1, Deleted in U twenty twenty, H-Robo-1, DUTT1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9Y6N7
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Gene ID
6091
Gene #
ROBO1
Shipping Temp
Blue Ice
Storage Temp
-20°C

Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000-1:2000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1097-1130 from human ROBO1 at C-terminal.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human ROBO1.
References
1. Kidd T.,et al.Cell 92:205-215(1998). 2. Muzny D.M.,et al.Nature 440:1194-1198(2006). 3. Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. 4. Bechtel S.,et al.BMC Genomics 8:399-399(2007). 5. Brose K.,et al.Cell 96:795-806(1999).
USBio References
No references available
Conjugates
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