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501913 Rabbit Anti-KDM6B, ID

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
O15054
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Mo
Gene ID
23135
Gene #
KDM6B
Shipping Temp
Blue Ice
Storage Temp
-20°C
Lysine-specific demethylase 6B, 11411-, JmjC domain-containing protein 3, Jumonji domain-containing protein 3, Lysine demethylase 6B, KDM6B, JMJD3, KIAA0346

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

Applications
Suitable for use in ELISA, Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:2000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within aa879-912 of the Central region of human KDM6B.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human KDM6B. Species Crossreactivity: mouse.
References
1. Nagase T.,et al.DNA Res. 4:141-150(1997).|2. Nakajima D.,et al.DNA Res. 9:99-106(2002).|3. Zody M.C.,et al.Nature 440:1045-1049(2006).|4. Hu L.Y.,et al.Gene Expr. 13:179-189(2006).|5. De Santa F.,et al.Cell 130:1083-1094(2007).
USBio References
No references available
Conjugates
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