CCR5

Clone Type

Polyclonal

Host

Goat

Source

Human

Swiss Prot

P51681

Isotype

IgG

Grade

Affinity Purified

Applications

E IHC WB

Crossreactivity

Hu Mc

Shipping Temp

Blue Ice

Storage Temp

-20°C

Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes. Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. Chemokines act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology.

C2099-98C binds to the CCR5 receptor on human spleen In Immunohistochemistry.

Applications

Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications have not been tested.

Recommended Dilution

ELISA: 1:25,000 Western Blot: 1:500 Immunohistochemistry (paraffin): 1:150 Optimal dilutions to be determined by the researcher.

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunogen

Synthetic peptide, YQVSSPIYDINYYTSEPCQKINVKQIAA, corresponding to aa3-30 within the N-terminal region of human CCR5.

Form

Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.09% sodium azide.

Purity

Purified by affinity chromatography.

Specificity

Recognizes human CCR5. Species Crossreactivity: macaque.

References

1. Brunn A, Montesinos-Rongen M, Strack A, Reifenberger G, Mawrin C, Schaller C, Deckert M. Expression pattern and cellular sources of chemokines in primary central nervous system lymphoma. Acta Neuropathol (Berl). 2007 Sep; 114(3):271-6.|2. van Loosdregt J, van Oosterhout MF, Bruggink AH, van Wichen DF, van Kuik J, de Koning E, Baan CC, de Jonge N, Gmelig-Meyling FH, de Weger RA. The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response. Circulation. 2006 Oct 10; 114(15):1599-607. |3. Thirkill TL, Vedagiri H, Douglas GC. Macaque trophoblast migration toward RANTES is inhibited by cigarette smoke-conditioned medium. Toxicol Sci. 2006 Jun; 91(2):557-67.|4. Elhini A, Abdelwahab S, Ikeda K. Th1 and Th2 cell population in chronic ethmoidal rhinosinusitis: a chemokine receptor assay. Laryngoscope. 2005 Jul; 115(7):1272-7. |5. Imamura Y, Kurokawa MS, Yoshikawa H, Nara K, Takada E, Masuda C, Tsukikawa S, Ozaki S, Matsuda T, Suzuki N. Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease. Clin Exp Immunol. 2005 Feb; 139(2):371-8.

USBio References

No references available

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C2099-98C Goat Anti-CCR5 (Chemokine Receptor 5, CC-CKR-5, CD195)

Clone Type

Host

Source

Swiss Prot

Isotype

Grade

Applications

Crossreactivity

Shipping Temp

Storage Temp

References

USBio References

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