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C5072-T1 Rabbit Anti-CIITA (Class II Trans Activator, C2TA, CIITA IV, MHC2TA, MHC class II transactivator) (Not for Export EU)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P33076
Isotype
IgG
Grade
Serum
Applications
E WB
Crossreactivity
Hu
Accession #
NP_000237.2
Gene ID
4261
Shipping Temp
Blue Ice
Storage Temp
-20°C

CIITA and Regulatory Factor X5 (RFX5) are two transcriptional activators identified in human patients with bare lymphocyte syndrome. They bind to "X boxes" in class II MHC gene promoters. X boxes are conserved among class II MHC genes in humans and mice. The X box sequence is 5'-GTNRCC(N 0-3 )RGYAAC-3' where N is any nucleotide, R is a purine, and Y is a pyrimidine. Patients with bare lymphocyte syndrome have no class I or class II MHC molecules due to a complete lack of transcription of class I and class II MHC genes. Both class I and class II MHC genes are flanked by 5’ promoter sequences, which are bound by specific transcription factors. Consequences of Bare Lymphocyte Syndrome are:an absence of cellular and humoral T cell immune responses.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Peptide corresponding to a region near the C-terminal end (aa726-742) of the human CIITA gene conjugated to KLH. Sequence: CGEIKDNKELPQYLALTTR
Form
Supplied as a liquid, 0.01% sodium azide.
Purity
Serum
Specificity
Monospecific for CIITA. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-rabbit serum.
References
Steimle, V., et al., (1993) Cell 53; 135–146. Cressman, D.E. et al. (1999) Immunity 10; 163. Harton, B. et al. (1999) Science 285, 1367.
USBio References
No references available
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