DOT1L (mammalian counterpart of yeast Dot1) is a 1537aa, 165kD (predicted) nuclear non-SET domain histone H3K79 methyltransferase. It is involved in developmental gene transcription and maintenance of chromatin structure, and may promote mixed lineage leukemia. Within the sequence used as an immunogen, human DOT1L shares 97%, 94% aa identity with mouse and rat DOT1L, respectively. Two human isoforms affect this region: a 1467aa form has an alternate start site at aa71, while a 1513aa form lacks aa89-112. A third isoform of 1739aa has a 202aa C-terminal extension.
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