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J5550-50A Rabbit Anti-JPO2 (CDCA7L, RAM2, Cell Division Cycle-associated 7-like Protein, Protein JPO2, Transcription Factor RAM2, HR1, R1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q96GN5
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu Mo
Accession #
NP_061189.2
Shipping Temp
Blue Ice
Storage Temp
-20°C

Cell division cycle-associated 7-like protein (or RAM2) is a transcription factor which plays a role in transcriptional regulation and apoptotic signaling pathways. It acts as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to promoter. It also plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. It may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 2-5ug/ml Optimal dilutions to be determined by the researcher.
Positive Control
HCT-116 (human) and NIH 3T3 (mouse) cell lysate
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa170-220 of human JPO2.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human JPO2. Species Crossreactivity: chimpanzee and mouse. Species sequence homology: bovine, canine, monkey.
References
1. Huang, A. et al. Cancer Res. 65:5607-5619 (2005). 2. Chen, K. et al. J. Biol. Chem. 280:11552-11559 (2005). 3. Ou, XM. et al. Proc. Natl. Acad. Sci. 103:10923-10928 (2006).
USBio References
No references available
Conjugates
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