neurofilament-3 (150 kD medium), neurofilament, medium polypeptide 150kDa, neurofilament triplet M protein, NFM, NF-M, NEF3, neurofilament, medium polypeptide, NEFM

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.