Pokemon is a 584aa protein containing 1 BTB (POZ) domain and 4 C2H2-type zinc fingers. It is involved in transcriptional regulation and influencing the switch from cellular proliferation to terminal differentiation. It is a cellular factor that preferentially associates with active chromatin and that can specifically stimulate Tat-activated HIV-1 transcription. Pokemon expression levels have been shown to predict biological behavior and clinical outcome.
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