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R9417-70K Goat Anti-Robo1 (Roundabout Axon Guidance Receptor Homolog 1, Roundabout 1, Roundabout-1, Roundabout Homolog 1, Roundabout Homolog-1 Precursor, Robo-1, Axon Guidance Receptor, Deleted in U Twenty Twenty, DUTT1, FLJ21882, H-Robo-1, MGC131599, MGC133277, SAX3)

Specifications
References
Clone Type
Polyclonal
Host
Goat
Source
Mouse
Isotype
IgG
Grade
Affinity Purified
Crossreactivity
Mo
Accession #
NP_062286.2
Shipping Temp
Blue Ice
Storage Temp
-20°C

Roundabout Homolog 1 (ROBO1) is a type I transmembrane protein belonging to the ROBO family, which defines a novel subfamily of immunoglobulin superfamily proteins. ROBO family proteins are evolutionarily conserved receptors that interact with the secreted Slit proteins. ROBO-Slit interactions play an important role in axon guidance across the midline during central nervous system development. ROBO signaling also has a role in tumor angiogenesis and immune responses.

Applications
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution
ELISA: 1:128,000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-QKARPAKKQKHQ, from the internal region of ROBO1/DUTT1 (NP_062286.2).
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
Purity
Purified by affinity chromatography.
Specificity
Recognizes ROBO1/DUTT1. Sequence homology: mouse, rat, canine.
References
1. Andrews W, Liapi A, Plachez C, Camurri L, Zhang J, Mori S, Murakami F, Parnavelas JG, Sundaresan V, Richards LJ. Robo1 regulates the development of major axon tracts and interneuron migration in the forebrain. Development. 2006 Jun;133(11):2243-52. PMID: 16690755.
USBio References
No references available
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