A sodium-dependent transport system is responsible for transfer and distribution of vitamins to different parts of the body, the transfer includes vitamins like pantothenate, biotin, and ascorbic acid etc, These transporters belong to Solute Carrier family (SLC). Since vitamins are required for essential metabolic processes in all mammalian cells, such cells have developed intrinsic mechanisms to active accumulation of essential vitamins. Thus transporters help these cells to fulfill their requirement, they include Sodium-dependent Multi-Vitamin Transporter (SMVT), Sodium-dependent Vitamin-C Transporter (SVCT) 1 & 2, Creatine Transporter (CRT1/ CT1). The other vitamin transporters from SLC family include Thiamine Transporter Protein 1 (THTR1), Folate Transporter or Reduced Folate Carrier 1 (RFC1), Thyroid Iodide Transporter (TIT) and Taurine Transporter (TAU) etc. Thiamine Transporter Protein 1 (THTR1),a 498aa protein in mouse and 497 in human (chrm 1q23.3, gene SLC19A2) is a high affinity transporter for the intake of Thiamine, Most abundantly found in skeletal and cardiac muscle, lower levels are seen in placenta, heart, liver and kidney. Defects in gene are the cause of Thiamine Responsive Megaloblastic Anemia (TRMA).