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4-1BB ligand, 71-254aa, Recombinant, Human (4-1BBL, CD137L, TNFSF9, Tumor necrosis factor ligand superfamily member 9)
4-1BB ligand, 71-254aa, Recombinant, Human (4-1BBL, CD137L, TNFSF9, Tumor necrosis factor
ligand superfamily member 9)
Pricing
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| 4-1BB ligand is a type 2 transmembrane glycoprotein belonging to the TNF superfamily. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with 4-1BBL strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murine models of cancer, infectious disease and autoimmune disease. Purified by using conventional chromatography. | | | Catalog # | 0004-01A | | Source | Recombinant human 4-1BB ligand, fused to His-tag at N-terminus, was expressed in E.coli. | | Molecular Weight | 23.8kD (222aa) | | Sequence of amino acids | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTG GLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL | | GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at 20 or 70°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Molecular Weight | 23.8kD | | Source | His-tagged, Recombinant, E. coli | | Purity | 95% by SDS-PAGE | | Concentration | ~1mg/ml | | Form | Supplied as liquid in 20 mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, | | 20% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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