| TNFSF9, a type II transmembrane glycoprotein and member of the TNF superfamily, preferentially expressed by B cells, which acts as a ligand for CD137 (4-1BB ligand receptor/TNFRSF9). Interaction between 4-1BBL and its receptor acts as a co-stimulatory signal for T cell activation and expansion, and is involved in the generation of cytotoxic T cells (Tc) and in the process of antigen presentation. Expression of 4-1BBL by a variety of carcinoma cells, suggests a role for 4-1BBL in tumor cell-T cell interactions. |
|
| Catalog # | 0004-01H |
| Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. |
| Recommended Dilution | ELISA: 0.5-2ug/ml |
| Western Blot: 0.1-0.2ug/ml |
| Optimal dilutions to be determined by the researcher. |
| Recommended Secondary Antibodies | Goat Anti Rabbit IgG (H&L) HRP |
| Sheep Anti Rabbit IgG Biotin |
| Goat Anti Rabbit IgG (Fc) FITC, HRP |
| Goat Anti Rabbit IgG (H&L) HRP |
| Sheep Anti Rabbit IgG FITC |
| Sheep Anti Rabbit IgG RPE |
| Sheep Anti Rabbit IgG DyLight™488, DyLight™549, DyLight™649 |
| Sheep Anti Rabbit IgG HRP |
| Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 100ul dH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For long term storage the addition of 0.09% sodium azide is recommended. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
| CAS Number | n/a |
| Clone Type | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Source | Human |
| Concentration | ~1mg/ml |
| Form | Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute in 100ul distilled water. |
| Purity | Purified by immunoaffinity chromatography. |
| Immunogen | Recombinant human 4-1BBL. |
| Specificity | Recognizes human 4-1BB Ligand, otherwise known as TNFSF9 |
|
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
