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4-1BB LIGAND, (TNFSF9, 4-1BBL, 4-1BB-L, Tumor necrosis factor ligand superfamily member 9), Recombinant Human
4-1BB LIGAND, (TNFSF9, 4-1BBL, 4-1BB-L, Tumor necrosis factor ligand superfamily member
9), Recombinant Human
Pricing
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| 4-1BB Ligand (4-1BBL/TNFSF9) is preferentially expressed by B cells, and is a ligand for CD137 (4-1BB ligand receptor/TNFRSF9). Interaction between 4-1BBL and its receptor acts as a co-stimulatory signal for T cell activation and expansion, and is involved in the generation of cytotoxic T cells and in the process of antigen presentation. Expression of 4-1BBL by a variety of carcinoma cells, suggests a role for 4-1BBL in tumor cell-T cell interactions. | | | Catalog # | 0004-01J | | Source | Purified recombinant 4-1BBL expressed in E.coli | | Activity | Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10 ng/ml. Please note: Results may vary with PBMC donors. | | Applications | Suitable for use in Functional Assays. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Endotoxin | 1EU/ug. | | Storage and Stability | Lyophilized powder may be stored at-20°C. Stable for 12 months at -20°C. Reconstitute with 200ul dH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 19.5kD | | Source | E. coli. | | Purity | 98% by SDS PAGE and HPLC analysis. | | Concentration | ~0.1mg/ml | | Form | Supplied as a lyophilized powder in PBS, pH 7.2, 1% BSA.. Reconstitute with 200ul dH2O. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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