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You are here:Home » Growth Factors, Cytokines » Growth Factors-Ligands » 4-1BB LIGAND, (TNFSF9, 4-1BBL, 4-1BB-L, Tumor necrosis factor ligand superfamily member 9), Recombinant Human

4-1BB LIGAND, (TNFSF9, 4-1BBL, 4-1BB-L, Tumor necrosis factor ligand superfamily member
9), Recombinant Human

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Specifications

4-1BB Ligand (4-1BBL/TNFSF9) is preferentially expressed by B cells, and is a ligand for CD137 (4-1BB ligand receptor/TNFRSF9). Interaction between 4-1BBL and its receptor acts as a co-stimulatory signal for T cell activation and expansion, and is involved in the generation of cytotoxic T cells and in the process of antigen presentation. Expression of 4-1BBL by a variety of carcinoma cells, suggests a role for 4-1BBL in tumor cell-T cell interactions.
Catalog #0004-01J
SourcePurified recombinant 4-1BBL expressed in E.coli
ActivityDetermined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10 ng/ml. Please note: Results may vary with PBMC donors.
ApplicationsSuitable for use in Functional Assays. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Endotoxin 1EU/ug.
Storage and StabilityLyophilized powder may be stored at-20°C. Stable for 12 months at -20°C. Reconstitute with 200ul dH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight19.5kD
SourceE. coli.
Purity98% by SDS PAGE and HPLC analysis.
Concentration~0.1mg/ml
FormSupplied as a lyophilized powder in PBS, pH 7.2, 1% BSA.. Reconstitute with 200ul dH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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