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You are here:Home » Antibodies » Antibodies-CD Markers » Anti -4-1BB Receptor (CD137, 4-1BB Ligand Receptor, TNFRSF9, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog) (PE)

Anti -4-1BB Receptor (CD137, 4-1BB Ligand Receptor, TNFRSF9, CDw137, ILA, MGC2172, T-cell
antigen 4-1BB homolog) (PE)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified FC
4-1BB is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFRSF9, CD137, and ILA. The 255aa human 4-1BB is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30kD glycoprotein exists both as a
monomer and as a dimer on T cells. The human and mouse proteins share 60% aa identity. 4-1BB is absent from naive T cells, but it is upregulated and continually expressed following T cell activation. The natural ligand, 4-1BBL, is a member of the TNF superfamily and is expressed on activated antigen presenting cells including dendritic cells, macrophages, and B cells. Cross- linking of 4-1BB by 4-1BBL or by agonistic antibodies transmits a potent co-stimulatory signal that enhances the effect of other activating signals such as PHA or anti-CD3 antibodies. 4-1BB signals through the TFAF2-NIK pathway resulting in activation of NF-kB and ultimately promoting proliferation and survival of T cells.
Catalog #0004-01L
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityStore product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No9H3
HostMouse
SourceHuman
Concentration~0.05mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
PurityPurified
ImmunogenSynthetic peptide corresponding to human 4-1BB/TNFRSF9.
SpecificityRecognizes human 4-1BB/TNFRSF9 (PE).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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