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You are here:Home » Antibodies » Abs to CD Markers » Anti -4-1BB (TNFRSF9, CD137, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor superfamily member 9 precursor)

Anti -4-1BB (TNFRSF9, CD137, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell
antigen ILA, Tumor necrosis factor receptor superfamily member 9 precursor)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B FC
4-1BB, also known as CD137, is a type I transmembrane protein belonging to the TNF
receptor superfamily (TNFRSF9). It is expressed on T cells, NK cells, monocytes,
neutrophils, dendritic cells, and eosinophils. The ligand for 4-1BB, 4-1BBL, is a TNF
ligand superfamily member (TNFSF9) expressed on the surfaces of activated antigen
presenting cells and T and B lymphoma cell lines. 4-1BB transduces a T cell
costimulatory signal to promote survival, proliferation, cytokine production, and effector
functions. On dendritic cells, 4-1BB ligation enhances cytokine production and
upregulates expression of B7-1 and B7-2 costimulatory molecules.
Catalog #0004-01N
ApplicationsSuitable for use in Flow Cytometry, ELISA, and Western Blot. Other applications not tested.
Recommended DilutionFlow Cytometry: 25ug/ml
ELISA: 0.5-1.0ug/ml
Western Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No9H5
HostMouse
SourceHuman
Concentration~500ug/ml
FormSupplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human 4-1BB aa24- 186 extracellular domain.
SpecificityRecognizes human 4-1BB/TNFRSF9.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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