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You are here:Home » Antibodies » Abs to Ligands » Anti -4-1BB Ligand (TNFRSF9, tumor necrosis factor receptor superfamily, member 9, 4-1BB, 4-1BB ligand receptor, CD137, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor superfamily member 9) (APC)

Anti -4-1BB Ligand (TNFRSF9, tumor necrosis factor receptor superfamily, member 9, 4-1BB,
4-1BB ligand receptor, CD137, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell
antigen ILA, Tumor necrosis factor receptor superfamily member 9) (APC)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified FC
4-1BB Ligand (4-1BBL; also CD137L) is a 32kD type II transmembrane protein that belongs to TNF superfamily (TNFSF) of molecules. The human 4-1BBL cDNA encodes a 254aa (aa) protein that contains a 25aa N-terminal cytoplasmic domain, a 23aa transmembrane segment, and a 206 aa C-terminal extracellular region. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. A 26kD soluble form of 4-1BBL is known to occur in human. Although it is presumably generated by MMP activity, its aa size is currently unreported. The soluble form is bioactive. Human 4-1BBL signals through both CD137/4-1BB and itself. Its cytoplasmic tail participates in reverse signaling that induces apoptosis in T cells and cytokine secretion (IL-6; TNF-alpha) by monocytes. 4-1BBL binding to
CD137/4-1BB produces a number of effects. Its seems to play a key role in the T cell recall response. It maintains T cell numbers at the end of a primary response, and induces CD4
and CD8 T cells to proliferate and secrete cytokines such as IL-2 and IFN-gamma in CD4 cells, and IFN-gamma in CD8 cells.
Catalog #0004-01S
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No9H2
HostMouse
SourceHuman
Concentration~50ug/ml
FormSupplied as a liquid in PBS containing 0.1% sodium azide.
PurityPurified
ImmunogenHuman 4-1BB Ligand.
SpecificityRecognizes human 4-1BB.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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