4-1 BB Receptor, Recombinant, Human, huIg Fusion Protein (CD137, 4-1BB Ligand Receptor,
TNFRSF9, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog)
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| Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3). CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily (1,2). CD137 appears to be important for T cell proliferation and survival (4). | | | Catalog # | 0004-02D | | Functional Application | CD137 Ig fusion protein blocks binding of anti-human CD137 to activated CEM human tumor cells and also binds to CD137 Ligand on Raji cells. | | Human CD137(4-1BB) huIg Fusion Protein* | | Molecular Structure | A soluble 55 kd fusion protein consisting of the extracellular (186aa) domain of human CD137 (4-1BB) fused to human IgG1 Fc (4). | | Transfectant Cell Line | CHO | | Applications | Suitable for use in ELISA and Flow cytometry. Other applications not tested. | | Recommended Dilution Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. | | | | Molecular Weight | 44.1kD | | Source | Recombinant, Human, CHO cells | | Purity | Purified by Protein A affinity chromatography. | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in FBS, 50mM sodium phosphate pH 7.5, 100mM potassium chloride, 150mM sodium chloride, 0.5mg/ml gentamicin sulfate. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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