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You are here:Home » Antibodies » Abs to Translation Initiation Factors » Anti -4E Binding Protein 1 (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP)

Anti -4E Binding Protein 1 (Protein Synthesis Initiation Factor 4E Binding Protein,
eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1), also called ELF4EBP1/BP-1/PHAS-I , is located on chromosome 8p12, with 118-amino acid protein (about 13kD). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non-phosphorylated eIF4EBP1 will bind strongly to eIF4E while the 24kD phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
Catalog #0004-22C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:10,000
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9A63
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.03% sodium azide.
PurityAscites
ImmunogenPurified truncated recombinant 4EBP1 expressed in E. coli strain BL21 (DE3).
SpecificityRecognizes human 4E Binding Protein 1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEukaryotic Translation Initiation Factor 4E Binding Protein 1, 4E-BP1, 4EBP1, BP-1, BP1, MGC4316, PHAS I, PHASI, Phosphorylated Heat and Acid Stable Protein Regulated by Insulin 1, eIF4E Binding Protein 1, eIF4EBP1


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