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14-3-3, tau (YWHAQ, 1C5, HS1, Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, theta Polypeptide), Recombinant, Human
14-3-3, tau (YWHAQ, 1C5, HS1, Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase
Activation Protein, theta Polypeptide), Recombinant, Human
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| The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms that have been identified in mammals. The 14-3-3 tau, a subtype of the 14-3-3 family of proteins, was found in T Cells, brain and testes. This 14-3-3 tau is upregulated in patients with amyotrophic lateral sclerosis. Recombinant human YWHAQ was expressed in E. coli and purified by using conventional chromatography techniques. | | | Catalog # | 0014-20 | | Source | Synthetic corresponding to aa1-245 of human 14-3-3, tau, expressed in E.coli. | | AA Sequences | MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR | | VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK | | MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE | | ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA | | EGAEN | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 27kD | | Source | Synthetic corresponding to aa1-245 of human 14-3-3, tau, expressed in E. coli. | | Purity | ~95% by SDS-PAGE. Purified by chromatography techniques. | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 20mM Tris pH7.5 | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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