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(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)
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| (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) is a synthetic analogue of curcumin that displays strong NAD(P)H:quinone reductase (NQO1) inducer potency in Hepa 1c1c7 cells. 2-HBA, a double Michael reaction acceptor, can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination which in turn enhances the expression of antioxidative and cytoprotective enzymes. 2-HBA has also been shown to cause G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis. | | | Catalog # | 004176 | | | | CAS Number | 131359-24-5 | | Molecular Formula | C17H14O3 | | Molecular Weight | 266.29 | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures. | | Alternate names | (1E,4E)-1,5-Bis(2-hydroxyphenyl)-1,4-pentadien-3-one; 2-HBA; (E,E)-1,5-Bis(2-hydroxyphenyl)-1,4-pentadien-3-one; |
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