17-N- CAS 467214-21-7

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010371 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride CAS: 467214-21-7

Specifications

References

CAS Number

467214-21-7

Grade

Highly Purified

Molecular Formula

C32H49ClN4O8

Molecular Weight

653.21

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride;

17-DMAG is an analogue of Gelamycin and 17-(Allylamino)geldanamycin. 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Form

Purple Solid

Melting Point

>270°C (dec.)

Solubility

DMSO, Methanol

References

Dote, H. et al.: Cancer Res., 66, 9211 (2006); Smith, V. et al.: Cancer Chemother. Pharmacol., 56, 126 (2005); Egorin, M.J. et al.: Cancer Chemother. Pharmacol., 49, 7 (2002);