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010951 Doramapimod CAS: 285983-48-4

Specifications
References
CAS Number
285983-48-4
Grade
Highly Purified
Molecular Formula
C31H37N5O3
Molecular Weight
527.66
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea; BIRB 796BS; Birb 796;

Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.

Form
Pale Beige Solid
Melting Point
136-139°C
Solubility
DMSO, Methanol
References
Pargellis, C. et al.: Nat. Struct. Biol., 9, 268 (2002,); Kuma, Y. et al.: J. Biol. CHem., 280, 19472 (2005); Yasui, H. et al.: Br. J. Haematol., 136, 414 (2007);
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