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011001 Drotaverine Hydrochloride CAS: 985-12-6

Specifications
References
CAS Number
985-12-6
Grade
Highly Purified
MDL Number
MFCD01754602
Molecular Formula
C₂₄H₃₂ClNO₄
Molecular Weight
433.97
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride; Isodihydroperparine Hydrochloride; NOSH-BRA; No-Spa; No-Spa Hydrochloride; Tetraspasmin-Lefa

Analogue of Papaverine. Antispasmodic Phosphodiesterase 4 inhibitor; anti-spasmodic agent.

Synonyms
1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride; Isodihydroperparine Hydrochloride; NOSH-BRA; No-Spa; No-Spa Hydrochloride; Tetraspasmin-Lefa
CAS No
985-12-6
Molecular Formula
C₂₄H₃₂ClNO₄
Molecular Weight
433.97
Appearance
Light yellow to yellow powder
Purity (1H NMR)
≥95%
Melting Point
>197ºC (dec.)
Solubility
DMSO (Slightly), Methanol (Slightly)
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Lalla, J., et al.: J. Pharm. Biomed. Anal., 11, 385 (1993). 2. Bolaji, O.O., et al.: Eur. J. Drug Metab. Pharmacokinet., 21, 217 (1996). 3. Kraemer, T., et al.: Drug Metab. Dispos., 28, 339. 4. Kapui, Z., Bence, J., Boronkay, E., et al. Behavioural effects of selective PDE4 inhibitors in relation to inhibition of catalytic activity and competition for [3H]rolipram binding. Neurobiology (Bp) 7(1), 71-73 (1999). 5. Tömösközi, Z., Finance, O., and Arányi, P. Drotaverine interacts with the L-type Ca2+ channel in pregnant rat uterine membranes. Eur. J. Pharmacol. 449(1-2), 55-60 (2002). 6. Madhu, C., Mahavarkar, S., and Bhave, S. A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour. Arch. Gynecol. Obstet. 282(1), 11-15 (2010).
USBio References
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