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015752 Mafosfamide CAS: 84211-05-2

Specifications
References
CAS Number
84211-05-2
Grade
Highly Purified
Molecular Formula
C9H18Cl2N2NaO5PS2
Molecular Weight
423.25
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
rel-2-[[(2R,4R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl]thio]ethanesulfonic Acid Sodium; Mafosfamid Sodium; Z 7557; cis-Mafosfamide Sodium

A Cyclophosphamide analog which induces apoptosis dose and time dependently in lymphoblastoid cells, with clearly more apoptosis in p53wt cells. Antitumor agent.

Synonyms
rel-2-[[(2R,4R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl]thio]ethanesulfonic Acid Sodium; Mafosfamid Sodium; Z 7557; cis-Mafosfamide Sodium
CAS No
84211-05-2 Free Acid: 88859-04-5
Molecular Formula
C9H18Cl2N2NaO5PS2
Molecular Weight
423.25
Purity
≥95%
Appearance
White to pale beige solid
Melting Point
>85°C (dec.) (lit)
Solubility
DMSO (slightly), Methanol (slightly)
Method for Determining Identity
Proton NMR and Mass Spectrometric Analysis
Elemental Analysis
Calculated: %C: 24.54, %H: 4.29, %N: 6.62
Sodium
As Reported
Atmosphere
Inert gas
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Very Hygroscopic. Store under inert atmosphere.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999), 2. Lips, J., et al.: Carcinogenesis, 22, 579 (2001). 3. Ward, I., et al.: J. Biol. Chem., 276, 47759 (2001),. 4. Zhou, B., et al.: Cancer Biol. Ther., 2, S16 (2003). 5. Roos, W., et al.: Oncogene, 26, 186 (2007)
USBio References
No references available
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