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Specifications

Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
Catalog #	018049
Melting Point	199-203ºC
Solubility	DMSO
Method for Determining Identity	Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions	SiO2: Dichloromethane: Methanol = 9.5: 0.5; Visualized with UV and AMCS; SIngle spot, Rf=0.6
Atmosphere	Inert gas
Storage and Stability	May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light sensitive.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
	All products should be handled by qualified personnel only, trained in laboratory procedures.
CAS Number	432531-71-0
Molecular Formula	C18H15N5O6S2
Molecular Weight	461.47
Source	Synthetic
Purity	~90%
Form	Supplied as a yellow solid
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	N-[4-[[(3-Methoxypyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide;