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You are here:Home » Biochemicals » Biochem-Protein Kinase Activators & Inhibitors » Necrosulfonamide

Necrosulfonamide

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Specifications

Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
Catalog #018049
Melting Point199-203ºC
SolubilityDMSO
Method for Determining IdentityProton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
TLC ConditionsSiO2: Dichloromethane: Methanol = 9.5: 0.5; Visualized with UV and AMCS; SIngle spot, Rf=0.6
Atmosphere Inert gas
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light sensitive.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards 
All products should be handled by qualified personnel only, trained in laboratory procedures.
CAS Number432531-71-0
Molecular FormulaC18H15N5O6S2
Molecular Weight461.47
SourceSynthetic
Purity~90%
FormSupplied as a yellow solid
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesN-[4-[[(3-Methoxypyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide;


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