SC-53116 Hydrochloride Hydrate CAS 879208-42-1

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020861 SC-53116 Hydrochloride Hydrate CAS: 879208-42-1

Specifications

References

CAS Number

879208-42-1

Grade

Highly Purified

Molecular Formula

C16H23Cl2N3O2 • xH2O

Molecular Weight

360.28

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4-Amino-5-chloro-N-[[(1S,7aS)-hexahydro-1H-pyrrolizin-1-yl]methyl]-2-methoxybenzamide Hydrochloride Hydrate; (1S-cis)-4-Amino-5-chloro-N-[(hexahydro-|1H-pyrrolizin-1-yl)methyl]-2-methoxybenzamide Hydrochloride Hydrate; |

SC-53116 is a 5-HT4 receptor partial agonist. SC-53116 has been shown to ameliorate scopolamine-induced impairment in learning in rats at a does of 10 μg/rat i.c.v and increase population spike amplitude in the CA1 and CA3 fields of the hippocampus at the same concentration.

Pfizer Compound

References

Robertson, D., et al.: J. Med. Chem., 29, 2 (1986), Hadley, M; Bioorg. Med. Chem. Lett., 9, 1147 (1992), Rivkin, A., et al.: Clin. Ther., 1952 (2003),