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Specifications

Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600.
Catalog #	022761
Melting Point	As Reported
Solubility	As Reported
Method for Determining Identity	Proton NMR (CD3OD and DMSO-d6), 19F NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions	As Reported
Ethyl Acetate	As Reported
Storage and Stability	May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
	All products should be handled by qualified personnel only, trained in laboratory procedures.
CAS Number	918504-65-1
Molecular Formula	C23H18ClF2N3O3S
Molecular Weight	489.92
Purity	~90%
Form	As Reported
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide; PLX 4032; RG 7204; Ro 51-85426;