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You are here:Home » Biochemicals » Biochem-Protein Kinase Activators & Inhibitors » Vemurafenib

Vemurafenib

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Specifications

Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600.
Catalog #022761
Melting PointAs Reported
SolubilityAs Reported
Method for Determining IdentityProton NMR (CD3OD and DMSO-d6), 19F NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis
TLC ConditionsAs Reported
Ethyl AcetateAs Reported
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards 
All products should be handled by qualified personnel only, trained in laboratory procedures.
CAS Number918504-65-1
Molecular FormulaC23H18ClF2N3O3S
Molecular Weight489.92
Purity~90%
FormAs Reported
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesN-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide; PLX 4032; RG 7204; Ro 51-85426;


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