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You are here:Home » Antibodies » Abs to Translation Initiation Factors » Anti -AGO3 (Protein Argonaute-3, Argonaute3, hAgo3, Eukaryotic Translation Initiation Factor 2C 3, eIF-2C 3, eIF2C 3, EIF2C3)

Anti -AGO3 (Protein Argonaute-3, Argonaute3, hAgo3, Eukaryotic Translation Initiation
Factor 2C 3, eIF-2C 3, eIF2C 3, EIF2C3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP IC
Eukaryotic translation initiation factor 2C 3, Ago3, belongs to the argonaute family and contains 1 PAZ and 1 Piwi domain. Ago3 is indicated to play a role in the RNA interference (RNAi) pathway, which is important for heterochromatin formation and accurate chromosome segregation. Unlike Ago1 and Ago2, Ago3 and AG04 do not possess the ability to dissociate miRNA duplexes in a minimal in vitro system. Re-introduction of any Ago variant into embyronic (ES) cells deficient for expression of all four Ago variants will rescue miRNA silencing defects and reduce apoptosis.
Catalog #029410
ApplicationsSuitable for use in Immunoprecipitation and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunocytochemistry: 1:500
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2ak
Clone No13A153
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to human AGO3.
SpecificityRecognizes human AGO3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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