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Abs to Angiotensin, Angiotensinogen
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Anti -Angiotensinogen (Serpin A8, AGT, SERPINA8)
Anti -Angiotensinogen (Serpin A8, AGT, SERPINA8)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IP IC |
|
| Angiotensinogen is a precursor of angiotensin-1,2, and 3; as a member of the serpin family, it is expressed by the liver and secreted in plasma. In response to lowered blood pressure, renin cleaves angiotensinogen and produce angiotensin-1. Angiotensin-converting enzyme (ACE) further removes a dipeptide to produce the physiologically active peptide angiotensin-2. Angiotensin-2 is involved in regulating mineral balance and volume of body fluids, while angiotensin-3 stimulates aldosterone release. Defects in angiotensinogen have been linked to renal tubular dygenesis (RTD) and susceptibility to essential hypertension. | | | Catalog # | 029417 | | Applications | Suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-10,000 | | Immunocytochemistry: 1:100-1:250 | | Immunoprecipitation: 1:10-1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Fetal artery, fetal heart, fetal liver, HepG2, 293T, and human plasma lysates | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 13A156 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol. | | Purity | Supernatant | | Immunogen | Synthetic peptide corresponding to human Angiotensinogen. | | Specificity | Recognizes human Angiotensinogen. Species Crossreactivity: Mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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