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You are here:Home » Antibodies » Abs to Angiotensin, Angiotensinogen » Anti -Angiotensinogen (Serpin A8, AGT, SERPINA8)

Anti -Angiotensinogen (Serpin A8, AGT, SERPINA8)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IC
Angiotensinogen is a precursor of angiotensin-1,2, and 3; as a member of the serpin family, it is expressed by the liver and secreted in plasma. In response to lowered blood pressure, renin cleaves angiotensinogen and produce angiotensin-1. Angiotensin-converting enzyme (ACE) further removes a dipeptide to produce the physiologically active peptide angiotensin-2. Angiotensin-2 is involved in regulating mineral balance and volume of body fluids, while angiotensin-3 stimulates aldosterone release. Defects in angiotensinogen have been linked to renal tubular dygenesis (RTD) and susceptibility to essential hypertension.
Catalog #029417
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-10,000
Immunocytochemistry: 1:100-1:250
Immunoprecipitation: 1:10-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlFetal artery, fetal heart, fetal liver, HepG2, 293T, and human plasma lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No13A156
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to human Angiotensinogen.
SpecificityRecognizes human Angiotensinogen. Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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