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Anti -ASCL2, CT (Achaete-scute Homolog 2, ASH-2, hASH2, Class A Basic Helix-loop-helix Protein 45, bHLHa45, Mash2, BHLHA45, HASH2) (FITC)
Anti -ASCL2, CT (Achaete-scute Homolog 2, ASH-2, hASH2, Class A Basic Helix-loop-helix
Protein 45, bHLHa45, Mash2, BHLHA45, HASH2) (FITC)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
FC |
|
| Achaete Scute homolog 2 is a nuclear protein expressed specifically in the extravillous trophoblasts of developing placenta. Placental development involves control by the basic helix-loop-helix transcription factor Achaete Scute homolog 2, which may regulate HIF (hypoxia) in the formation of spongiotrophoblasts. Targeted mutagenesis of Achaete Scute homolog 2 yielded loss of function results in embryonic lethality at midgestation due to placental failure associated with a lack of spongiotrophoblasts and reduced labyrinthine trophoblast layers. In addition to healthy placental development, Achaete Scute proteins may also be involved in the determination of neuronal precursors in the central and peripheral nervous systems. Achaete Scute homolog 2 has also been implicated as a controller of intestinal stem cell fate and is essential for the maintenance of adult intestinal stem cells. | | | Catalog # | 029419 | | Applications | Suitable for use in Flow Cytometry. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Positive Control | 2102 Ep human embryonal carcinoma cells | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2bk | | Clone No | 13A157 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.1% sodium azide, 15mg/ml BSA. Labeled with fluorescein isothiocyanate (FITC). | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant corresponding to human Achaete Scute homolog 2 fused to His-tag at C-terminal. | | Specificity | Recognizes human Achaete Scute homolog 2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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