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You are here:Home » Antibodies » Abs to Chromatin Proteins » Anti -BAF57 (SWI/SNF-related Matrix-associated Actin-dependent Regulator of Chromatin Subfamily E Member 1, BRG1-associated Factor 57, BAF57 SMARCE1)

Anti -BAF57 (SWI/SNF-related Matrix-associated Actin-dependent Regulator of Chromatin
Subfamily E Member 1, BRG1-associated Factor 57, BAF57 SMARCE1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
BAF57, also known as SMARCE1, is a core subunit of the SWI/SNF complex, which is required for transcriptional activation of genes normally repressed by chromatin. The SWI/SNF chromatin remodeling complex is critical for androgen receptor transcriptional and the BAF57 subunit facilitates direct interaction with the receptor. Studies suggest a blockade of the androgen receptor-BAF57 interaction may target agonisty-induced androgen receptor function. Data also suggest that the SWI/SNF complex is required for transcriptional activation by the estrogen receptor. ChIP assays demonstrated BAF57 is recruited to the estrogen-response promoter, pS2.
Catalog #029424
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml
Immunohistochemistry: 1:300
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic linear peptide corresponding to human BAF57 at the HMG box region (KLH).
SpecificityRecognizes human BF57. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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