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You are here:Home » Antibodies » Abs to Autophagy » Anti -DRAM2 (DNA Damage-regulated Autophagy Modulator Protein 2, Transmembrane Protein 77, TMEM77, PSEC0031, UNQ154/PRO180)

Anti -DRAM2 (DNA Damage-regulated Autophagy Modulator Protein 2, Transmembrane Protein 77,
TMEM77, PSEC0031, UNQ154/PRO180)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Damage-Regulated Autophagy Modulator is a lysosomal protein that acts as an effector molecule that is critical for autophagy and p53-mediated apoptosis. In humans, there are 5 known proteins that show significant homology to DRAM. The closest of these proteins is DRAM2, which displays 67% conservation when compared to DRAM. However, unlike DRAM, DRAM2 is not induced by p53 or p73. Additionally, it does not modulate autophagy in contrast with DRAM. DRAM2 is known to be co-localized with DRAM in lysosomes, and co-expression with DRAM is shown to significantly increase cell death.
Catalog #029456
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot:1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman placenta tissue lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2ak
Clone No13A175
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic linear peptide corresponding to human DRAM2.
SpecificityRecognizes human DRAM2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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