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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -Keratocan (KTN, Corneal Keratan Sulfate Proteoglycan 37A Core Protein, Keratan Sulfate Proteoglycan Keratocan, KSPG Keratocan, KERA)

Anti -Keratocan (KTN, Corneal Keratan Sulfate Proteoglycan 37A Core Protein, Keratan
Sulfate Proteoglycan Keratocan, KSPG Keratocan, KERA)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified B IH
Keratocan is an extracellular matrix protein that belongs to the small leucine-rich proteoglycan (SLRP) family that also includes lumican, biglycan, decorin, mimecan, and fibromodulin. Members of this family are known to regulate cellular processes, such as proliferation and modulation of osteoprogenitor lineage differentiation. Keratocan is differentially expressed by osteoblasts and shows little or no expression in osteocytes. Lumican and Keratocan are the major keratan sulfate (KS) proteoglycans in corneal stroma. Both proteins are critical for normal cornea morphogenesis during embryonic development and maintenance of corneal topography in adults. It is shown that homozygous Keratocan knockout mice display abnormal corneas, significantly decreased rates of bone formation and mineral apposition, larger fibril diameters, and disorganized fibril spacing. Keratocan mutation leads to cornea plana in humans, which is often associated with glaucoma. Experimental evidence indicates that lumican may have additional biological functions, such as modulation of cell migration and epithelium-mesenchyme transition in wound healing and tumorgenesis, aside from regulating collagen fibrillogenesis.
Catalog #029526
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlRat eye tissue lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM
Clone No13A204
HostMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PurityPurified by Ion Exchange chromatography.
ImmunogenKeratocan from partially purified keritinase II-treated bovine corneal extract.
SpecificityRecognizes rat Keratocan. Species sequence homology: bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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