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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -MAP-2 (Microtubule-associated Protein 2, Map2, Mtap2) (Biotin)

Anti -MAP-2 (Microtubule-associated Protein 2, Map2, Mtap2) (Biotin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. MAP-2 is essential for the development and maitenance of neuronal morphology. Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation. All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31aa motif. MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.
Catalog #029533
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:100
Optimal dilutions to be determined by the researcher.
Positive ControlAdult mouse brain tissue
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in PBS, 0.1% sodium azide, 15mg/ml BSA. Labeled with Biotin.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic linear peptide corresponding to rat MAP-2 (KLH).
SpecificityRecognizes rat MAP-2. Species Crossreactivity: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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