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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -MAP2 (Microtubule-associated Protein 2, MAP-2) (Cy3)

Anti -MAP2 (Microtubule-associated Protein 2, MAP-2) (Cy3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IC
The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology. Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation. All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31aa motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.
Catalog #029534
ApplicationsSuitable for use in Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunocytochemistry: 1:100
Optimal dilutions to be determined by the researcher.
Positive ControlRat E18 primary cortex cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Cy conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No13A207
HostMouse
ConcentrationNot determined
FormSupplied as a liquid in PBS, 0.1% sodium azide, 15mg/ml BSA. Labeled with Cy3.
PurityPurified by Protein A affinity chromatography.
ImmunogenBovine brain microtubule protein.
SpecificityRecognizes rat MAP2. Species sequence homology: Bovine, chicken, human, and mouse (100%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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