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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NLRP7 (NACHT, LRR and PYD Domains-containing Protein 7, Nucleotide-binding Oligomerization Domain Protein 12, PYRIN-containing APAF1-like Protein 3, NALP7, NOD12, PYPAF3)

Anti -NLRP7 (NACHT, LRR and PYD Domains-containing Protein 7, Nucleotide-binding
Oligomerization Domain Protein 12, PYRIN-containing APAF1-like Protein 3, NALP7, NOD12,
PYPAF3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
NLRPs are members of NLR (Nod-like receptors) protein family. NRLP genes are known to play important roles in both the mammalian reproductive system and the innate immune system. Several NRLP genes are specifically expressed in mammal oocytes. Through multiprotein complexes called inflammasomes, NRLP proteins are through to activate proinflammatory caspases. In humans, NRLP7 mutations are found to cause a recurrent hydatidiform of molar pregnancies, stillbirths, spontaneous abortions, and intrauterine growth retardation. Patients with NLRP7 mutations display an impaired inflammatory response to various stimuli. Furthermore, molar tissues analyzed from these patients are found to be diploid and biparental. It is reported that ten non-synonymous variants and one stop codon are found in patients with NLRP7 mutations, but not in controls.
Catalog #029560
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlMouse brain tissue lysate.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic linear peptide corresponding to human NLRP7 (KLH).
SpecificityRecognizes NLRP7. Species sequence homology: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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