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Anti -Pericentrin (Kendrin, Pericentrin-B, PCNT, KIAA0402, PCNT2)
Anti -Pericentrin (Kendrin, Pericentrin-B, PCNT, KIAA0402, PCNT2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IC |
|
| Pericentrin binds to calmodulin and is expressed in the centrosome that serves as a multifunctional scaffold for anchoring proteins and protein complexes. Evidence suggests that pericentrin plays a role in microtubule nucleation and spindle organization. Recent studies show pericentrin plays a role in Majewski/micorcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel Syndrome. Recent use in network modeling indicates a direct link between breast cancer susceptibility to centrosome defects. Pericentrin is a potential marker for centrosome defects in cancer and cancer progression, as centrosomal abonormalities in solid tumors are accompanied by increased pericentrin levels and defects in pericentrin organization. | | | Catalog # | 029579 | | Applications | Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5ug/ml | | Immunocytochemistry: 1:500 | | Optimal dilutions to be determined by the researcher. | | Positive Control | HeLa cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic linear peptide corresponding to human Pericentrin (KLH). | | Specificity | Recognizes human Pericentrin. Species sequence homology: Mouse (89%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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