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Anti -SPRED2 (Sprouty-related, EVH1 Domain-containing Protein 2, Spred-2)
Anti -SPRED2 (Sprouty-related, EVH1 Domain-containing Protein 2, Spred-2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| The Sprouty/Spread family of proteins contains three members, which share high sequence homology for the cysteine-rich domain (CRD), and are shown to inhibit Ras/ERK signaling. Along with its other family members, Spred-2 inhibits Ras/MAP kinase activity (mediated by the epidermal growth factor receptor and the fibroblast growth factor receptor) by binding to Ras and thereby preventing Raf phosphorylation. Like Spred-1, Spred-2 competes with substrates Tau and STAT3 for the DYRK1a kinase domain and thereby inhibits DYRK1a substrate phosphorylation. It is reported that Spred-2 appears to be involved in cytoplasmic vesicle transport and in other metabolic signaling. | | | Catalog # | 029615 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | PC-3 cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic linear peptide corresponding to human Spred-2 (KLH). | | Specificity | Recognizes human Spred-2. Species sequence homology: Mouse, rat (89%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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