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You are here:Home » Antibodies » Antibodies-Transcription Factors, STAT » Anti -STAT3, phosphorylated (Tyr68) (Signal Transducer and Activator of Transcription 3, Acute-phase Response Factor, APRF)

Anti -STAT3, phosphorylated (Tyr68) (Signal Transducer and Activator of Transcription 3,
Acute-phase Response Factor, APRF)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
This protein is a member of the family of STAT proteins. These proteins are latent cytoplasmic transcription factors with the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. The Stat3 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, onM, LIF, CNTF, G-CSF, IL-12, IL-2, GH, EGF, PDGF, and CSF-1. Stat3 is not activated by IFN beta. One active Stat3 translocates to the nucleus and binds to DNA as either a homodimer or as a heterodimer with Stat1. Transcription factors associated with Stat3 include cJun and cyclic AMP responsive enhancer binding protein (CREB). Stat3 interacts with the APRE (acute phase response element) and the SIE (c-sis inducible element).
Catalog #029618
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlPMA treated and untreated MOLT4 cell lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic linear peptide corresponding to human STAT3 phosphorylated at Tyr68 (KLH).
SpecificityRecognizes human STAT3 phosphorylated at Tyr68. Species sequence homology: Mouse, rat, bovine, porcine, xenopus, chicken (100%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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