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You are here:Home » Molecular Biology » MB-Neurotrophins » CLCF1, Recombinant, Human, aa28-225, His-Tag (Cardiotrophin-like Cytokine Factor 1, B Cell-stimulating Factor 3, BSF-3, Novel Neurotrophin-1, NNT-1, BSF3, CLC, NNT1)

CLCF1, Recombinant, Human, aa28-225, His-Tag (Cardiotrophin-like Cytokine Factor 1, B
Cell-stimulating Factor 3, BSF-3, Novel Neurotrophin-1, NNT-1, BSF3, CLC, NNT1)

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Specifications

CLCF1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225aa with a 27aa signal peptide, a molecular mass of 22kD in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine.
Catalog #029649
SourceRecombinant corresponding to aa28-225 from human CLCF1, fused to His-tag, expressed in E.coli.
AA SequenceMGSSHHHHHH SSGLVPRGSH MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF
Molecular Weight~24.6kD
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~24.6kD
SourceE.coli
Purity~90% (SDS-PAGE)
Concentration~1mg/ml
FormSupplied as a liquid in 20mM sodium citrate, pH 3.5, 0.4M urea, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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