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You are here:Home » Antibodies » Abs to Insulin » Anti -Insig1 (Insulin-induced Gene 1 Protein, INSIG-1, Immediate-early Protein CL-6, Insulin-induced Growth Response Protein CL-6, Cl-6)

Anti -Insig1 (Insulin-induced Gene 1 Protein, INSIG-1, Immediate-early Protein CL-6,
Insulin-induced Growth Response Protein CL-6, Cl-6)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Insulin-induced gene (InSig) localizes in the endoplasmic recticulum(ER) and is highly expressed in the liver and fibroblast cell lines. InSig1 and InSig2 play important roles in the regulation of cholesterol biosynthesis. Sterol induces InSig1 binding to the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Both InSig1 and Insig2 prevent the export of SCAP from the ER and thus, inhibit cholesterol synthesis by preventing the proteolytic cleavage of SREBPs by the Golgi enzymes.
Catalog #029830
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa248 from rat Insig1.
SpecificityRecognizes rat InSig-1 at ~30kD and its precursor (~50kD). Species Crossreactivity: human, mouse, hamster and bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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