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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -ABCB5 (ATP-binding cassette, sub-family B MDR/TAP, ABCB5alpha, ABCB5beta, EST422562, ATP-binding cassette, sub-family B, member 5N: P-glycoprotein ABCB5)

Anti -ABCB5 (ATP-binding cassette, sub-family B MDR/TAP, ABCB5alpha, ABCB5beta, EST422562,
ATP-binding cassette, sub-family B, member 5N: P-glycoprotein ABCB5)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse E B IH IC FC
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules
Catalog #029928
ABCB5 (ATP-binding cassette, subfamily B [DR/TAP] member 5) is a 90kD (predicted MW) member of the human P-glycoprotein family of molecules. It is expressed by CD133+ pluripotent pigment stem cells, where it serves as a marker for cells that show a high incidence of polyploidy. Human ABCB5 is 812aa in length. It is possibly a five transmembrane protein with a 247aa N-terminal extracellular domain (ECD) aa1-247 and a 283aa C-terminal cytoplasmic region aa530-812. The ECD contains one ABC transporter aa2-177, while the cytoplasmic region contains a second ABC transporter aa570-808. There are two potential splice forms. One shows a seven aa substitution for aa125-812, while another possesses an alternative start site 445aa upstream of the standard site. Over aa141-247, human ABCB5 shares 64aa identity with mouse ABCB5.
ApplicationsWestern Blot: 1:500-1:2000
Immunohistochemistry: 1:200-1:1000
Immunocytochemistry: 1:200-1:1000
Flow Cytometry: 1:200-1:400
ELISA: 1:10000
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No13B6
HostMouse
SourceHuman
ConcentrationAs reported
FormPurified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
PurityPurified
ImmunogenPurified recombinant fragment of human ABCB5 (AA: 481-674) expressed in E. coli.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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