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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -BTK (Tyrosine-protein Kinase BTK, Agammaglobulinaemia Tyrosine Kinase, ATK, B-cell Progenitor Kinase, BPK, Bruton Tyrosine Kinase, AGMX1, ATK, BPK)

Anti -BTK (Tyrosine-protein Kinase BTK, Agammaglobulinaemia Tyrosine Kinase, ATK, B-cell
Progenitor Kinase, BPK, Bruton Tyrosine Kinase, AGMX1, ATK, BPK)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse E B IH
Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.
Catalog #030007
ApplicationsWestern Bloting: 1:500-1:2000.
Immunohistochemistry: 1:200-1:1000.
Immunofluorescence: 1:200-1:1000.
ELISA: Suggested dilution 1:10000.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No13B85
HostMouse
SourceHuman
ConcentrationNot determined
FormAscites fluid, 0.03% sodium azide.
PurityAscites
ImmunogenPurified recombinant fragment of BTK expressed in E. coli.
SpecificityHuman, Monkey
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesBTK


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