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You are here:Home » Antibodies » Abs to Disease Markers » Anti -DCX (Doublecortin)

Anti -DCX (Doublecortin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse E B IH IC FC
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Catalog #030140
ApplicationsWestern Blot: 1:500-1:2000
Immunohistochemistry: 1:200-1:1000
Immunocytochemistry: 1:200-1:1000
Flow Cytometry: 1:200-1:400
ELISA: 1:10000
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No13B218
HostMouse
SourceHuman
ConcentrationNot determined
FormPurified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
<br>
PurityPurified
ImmunogenPurified recombinant fragment of human DCX (AA: 362-411) expressed in E. coli.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDC; DBCN; LISX; SCLH; XLIS


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