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You are here:Home » Antibodies » Abs to Centromeres » Anti -INCENP (Inner centromere protein)

Anti -INCENP (Inner centromere protein)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse E B IH IC FC
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF:mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis
Catalog #030340
ApplicationsWestern Blot: 1:500-1:2000
Immunohistochemistry: 1:200-1:1000
Immunocytochemistry: 1:200-1:1000
Flow Cytometry: 1:200-1:400
ELISA: 1:10000
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No13B418
HostMouse
SourceHuman
ConcentrationNot determined
FormPurified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
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PurityPurified
ImmunogenPurified recombinant fragment of human INCENP (AA: 369-583) expressed in E. coli.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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