LPA: lipoprotein, Lp(a). Apo(a) is the main constituent of lipoprotein(a) (lp(a)). It has serine proteinase activity and is able of autoproteolysis. It inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/gp 330. Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-lp(a). Apo(a) fragments accumulate in atherosclerotic lesions,where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation.
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