Anti -BLNK (BLNK, BASH, SLP65, B-cell linker protein, B-cell adapter containing a SH2
domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic
adapter protein, Src homology 2 domain-containing leukocyte protein of 65kD)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
E B |
|
| This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. | | | Catalog # | 030807 | | Applications | Suitable for use in Western Blot, ELISA. | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:500~8000 | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgM | | Clone No | 520CT6.1.1 | | Host | Mouse | | Source | Human | | Concentration | Crude ascites | | Form | Supplied as a liquid, crude ascites with 0.09% sodium azide. | | Purity | Ascites | | Immunogen | Purified His-tagged BLNK protein (fragment). | | Specificity | Human | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | BLNK, BASH, SLP65, B-cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65kD |
External Links
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