Anti -CASP2 (CASP8, MCH5, Caspase-8, Apoptotic cysteine protease, Apoptotic protease
Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, ICE-like apoptotic
protease 5, MORT1-associated ced-3 homolog, Caspase-8 subunit p18, Caspase-8 subunit p10
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
E B |
|
| This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq]. | | | Catalog # | 030831 | | Applications | Suitable for use in Western Blot, ELISA. | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:1000~16000 | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 550CT8.5.2 | | Host | Mouse | | Source | Human | | Concentration | Crude ascites | | Form | Supplied as a liquid, crude ascites with 0.09% sodium azide. | | Purity | Ascites | | Immunogen | CASP2 Mab is generated from mouses immunized with a KLH conjugated synthetic peptide selected from human CASP2. | | Specificity | Human | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | CASP8, MCH5, Caspase-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, Caspase-8 subunit p18, Caspase-8 subunit p10 |
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Download Specifications for Anti -CASP2 (CASP8, MCH5, Caspase-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, Caspase-8 subunit p18, Caspase-8 subunit p10 |
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